Article
The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
Bone - 1 Dec 2015
Tsoumpra Maria K, Muniz Joao R, Barnett Bobby L, Kwaasi Aaron A, Pilka Ewa S, Kavanagh Kathryn L, Evdokimov Artem, Walter Richard L, Von Delft Frank, Ebetino Frank H, Oppermann Udo, Russell R Graham G, Dunford James E
Abstract excerpt
Farnesyl pyrophosphate synthase (FPPS) is the major molecular target of nitrogen-containing bisphosphonates (N-BPs), used clinically as bone resorption inhibitors. We investigated the role of threonine 201 (Thr201) and tyrosine 204 (Tyr204) residues in substrate binding, catalysis and inhibition...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.