Article
Polymorphisms of the farnesyl diphosphate synthase gene modulate bone changes in response to atorvastatin.
Rheumatology international - 1 Aug 2014
Pérez-Castrillón José L, Zarrabeitia María T, Abad Laura, Vega Gemma, Ruiz-Mambrilla Marta, Gonzalez-Sagredo Manuel, Dueñas-Laita Antonio, Riancho José A
Abstract excerpt
Although their primary therapeutic indications are different, aminobisphosphonates and statins target enzymes in the mevalonate pathway, which is critical for bone homeostasis. Previous studies have shown that some polymorphisms of the gene encoding farnesyl diphosphate synthase (FDPS), the main target of aminobisphosphonates, modulate the response to these drugs. In this study, we explored whether those single...
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