Article
Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw.
Frontiers in bioscience (Elite edition) - 1 Jan 2011
Marini Francesca, Tonelli Paolo, Cavalli Loredana, Cavalli Tiziana, Masi Laura, Falchetti Alberto, Brandi Maria Luisa
Abstract excerpt
An undesirable effect associated with bisphosphonates is osteonecrosis of the jaw (ONJ). Case reports discussed ONJ development in patients with multiple myeloma or metastatic cancers receiving bisphosphonates as palliation for malignant bone disease. No causative relationship has been unequivocally demonstrated between ONJ and bisphosphonate therapy. To determine if a higher sensitivity to bisphosphonates could...
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