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Article

Common allelic variants of the farnesyl diphosphate synthase gene influence the response of osteoporotic women to bisphosphonates.

The pharmacogenomics journal - 1 Jun 2012

Olmos J M, Zarrabeitia M T, Hernández J L, Sañudo C, González-Macías J, Riancho J A

Abstract excerpt

Farnesyl diphosphate synthase (FDPS) is necessary for osteoclast survival and activity and is considered as a major molecular target of aminobisphosphonates. Our objective was to analyze the influence of FDPS polymorphisms on bone mineral density (BMD) and the response to antiresortive drugs. Three single-nucleotide polymorphisms of FDPS were analyzed in 1186 postmenopausal women. There was only a marginally...

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Source

Identifiers

PMID: 21151198
DOI: 10.1038/tpj.2010.88

Genes

FDPS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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