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Article

Variation near complement factor I is associated with risk of advanced AMD.

European journal of human genetics : EJHG - 1 Jan 2009

Fagerness Jesen A, Maller Julian B, Neale Benjamin M, Reynolds Robyn C, Daly Mark J, Seddon Johanna M

Abstract excerpt

A case-control association study for advanced age-related macular degeneration was conducted to explore several regions of interest identified by linkage. This analysis identified a single nucleotide polymorphism just 3' of complement factor I on chromosome 4 showing significant association (P<10(-7)). Sequencing was performed on coding exons in linkage disequilibrium with the detected association. No obvious...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18685559
DOI: 10.1038/ejhg.2008.140
PMCID: PMC2985963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variation near complement factor I is associated with risk of advanced AMD.PMID 18685559Read ↗

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[Association of single nucleotide polymorphism in complement factor I gene with age-related macular degeneration].Semantic proximity Read ↗

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Complement factor H polymorphism and age-related macular degeneration.Semantic proximity Read ↗

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.Semantic proximity Read ↗

Rare Dysfunctional Complement Factor I Genetic Variants and Progression to Advanced Age-Related Macular DegenerationSemantic proximity Read ↗

Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progressionSemantic proximity Read ↗

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No evidence of association between complement factor I genetic variant rs10033900 and age-related macular degenerationSemantic proximity Read ↗

Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration.Semantic proximity Read ↗

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