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Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization

18 Mar 2022

Abstract excerpt

Purpose Risk of advanced age-related macular degeneration (AAMD) is associated with rare genetic variants in the gene encoding complement factor I ( CFI ), which is associated with lower circulating CFI protein levels, but the nature of the relationship is unclear. Can genetic factors be used to infer whether low circulating CFI is associated with AAMD risk? Design Two-sample inverse variance-weighted Mendelian...

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PMID: 35693873
DOI: 10.1016/j.xops.2022.100146

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