Back to search

Article

Rare Dysfunctional Complement Factor I Genetic Variants and Progression to Advanced Age-Related Macular Degeneration

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>PURPOSE</h4> To evaluate associations between rare dysfunctional Complement Factor I ( CFI ) genetic variant status and progression to advanced age-related macular degeneration (AAMD), geographic atrophy (GA) and neovascular disease (NV). <h4>DESIGN</h4> Prospective, longitudinal study <h4>PARTICIPANTS</h4> Patients aged 55-80 years at baseline identifying as white with non-advanced AMD in on...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
07c0d71f-675b-5067-8bab-dcd415e50b08
DOI
10.1101/2022.12.20.22283695
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Rare Dysfunctional Complement Factor I Genetic Variants and Progression to Advanced Age-Related Macular DegenerationDOI 10.1101/2022.12.20.22283695
Rare Dysfunctional Complement Factor I Genetic Variants and Progression to Advanced Age-Related Macular DegenerationSemantic proximity
Rare and Common Genetic Variants, Smoking and Higher Body Mass Index Are Associated with Earlier Age of Progression to Geographic Atrophy and Neovascular Advanced Stages of Macular Degeneration in a Prospective AnalysisSemantic proximity
Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank.Semantic proximity
Rare and Common Genetic Variants, Smoking, and Body Mass Index: Progression and Earlier Age of Developing Advanced Age-Related Macular Degeneration.Semantic proximity
Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels.Semantic proximity
Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian RandomizationSemantic proximity
Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration.Semantic proximity
Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population.Semantic proximity
An assessment of prevalence of Type 1 CFI rare variants in European AMD, and why lack of broader genetic data hinders development of new treatments and healthcare access.Semantic proximity
Genetic Insights into Age-Related Macular DegenerationSemantic proximity
The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment.Semantic proximity
Genetic variants in the complement system predisposing to age-related macular degeneration: a review.Semantic proximity
Select a neighboring publication to make it the new centre.