Article
HLA-DR and the development of rheumatoid arthritis.
Autoimmunity - 1 Jan 1997
Auger I, Roudier J
Abstract excerpt
Susceptibility to develop Rheumatoid arthritis (RA) maps to a highly conserved amino acid motif ("the shared epitope") expressed in the third hypervariable region of different HLA-DRB1 alleles. This motif, namely QKRAA, QRRAA or RRRAA helps the development of RA by an unknown mechanism. However,...
Topics
- Alleles
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Binding Sites
- Epitope Mapping
- HLA-DR Antigens
- HSP70 Heat-Shock Proteins
- Humans
- Molecular Sequence Data
- Sequence Alignment
- T-Lymphocytes