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Article

ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.

Virology - 30 Sept 2008

Bryant Kevin F, Macari Elizabeth R, Malik Natasha, Boyce Michael, Yuan Junying, Coen Donald M

Abstract excerpt

The small molecule salubrinal has antiviral activity against herpes simplex virus-1 (HSV-1) and inhibits dephosphorylation of eIF2 alpha mediated by the HSV-1 protein ICP34.5. We investigated whether salubrinal's activities in infected cells depend on ICP34.5. An ICP34.5 deletion mutant was as sensitive as wild type HSV-1 to salubrinal inhibition of plaque formation in Vero cells. However, salubrinal induced...

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Identifiers

PMID: 18684481
DOI: 10.1016/j.virol.2008.06.028
PMCID: PMC2665023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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