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Article

Analysis of the Role of Autophagy in Replication of Herpes Simplex Virus in Cell Culture

14 Sept 2007

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) neurovirulence gene encoding ICP34.5 controls the autophagy pathway. HSV-1 strains lacking ICP34.5 are attenuated in growth and pathogenesis in animal models and in primary cultured cells. While this growth defect has been attributed to the inability of an ICP34.5-null virus to counteract the induction of translational arrest through the PKR antiviral pathway, the role of...

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PMID: 17855538
DOI: 10.1128/jvi.01356-07

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