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Article

Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.

Molecular systems biology - 1 Jan 2008

Chou Song, Zhao Su, Song You, Liu Haoping, Nie Qing

Abstract excerpt

The yeast transcription factor Ste12 controls both mating and filamentation pathways. Upon pheromone induction, the mitogen-activated protein kinases, Fus3 and Kss1, activate Ste12 by relieving the repression of two functionally redundant Ste12 inhibitors, Dig1 and Dig2. Mating genes are controlled by the Ste12/Dig1/Dig2 complex through Ste12-binding sites, whereas filamentation genes are regulated by the...

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Identifiers

PMID: 18682702
DOI: 10.1038/msb.2008.47
PMCID: PMC2538907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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