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Article

Combinatorial control required for the specificity of yeast MAPK signaling.

Science (New York, N.Y.) - 28 Feb 1997

Madhani H D, Fink G R

Abstract excerpt

In yeast, an overlapping set of mitogen-activated protein kinase (MAPK) signaling components controls mating, haploid invasion, and pseudohyphal development. Paradoxically, a single downstream transcription factor, Ste12, is necessary for the execution of these distinct programs. Developmental specificity was found to require a transcription factor of the TEA/ATTS family, Tec1, which cooperates with Ste12 during...

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Identifiers

PMID: 9036858
DOI: 10.1126/science.275.5304.1314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Combinatorial control required for the specificity of yeast MAPK signaling.PMID 9036858Read ↗

Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth.Semantic proximity Read ↗

Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.Semantic proximity Read ↗

Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast.Semantic proximity Read ↗

Phenotypic and transcriptional plasticity directed by a yeast mitogen-activated protein kinase network.Semantic proximity Read ↗

Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.Semantic proximity Read ↗

Ste12 and Ste12-Like Proteins, Fungal Transcription Factors Regulating Development and PathogenicitySemantic proximity Read ↗

Tec1 and Ste12 transcription factors play a role in adaptation to low pH stress and biofilm formation in the human opportunistic fungal pathogen Candida glabrataSemantic proximity Read ↗

The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components.Semantic proximity Read ↗

Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.Semantic proximity Read ↗

Elements of the yeast pheromone response pathway required for filamentous growth of diploids.Semantic proximity Read ↗

Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.Semantic proximity Read ↗

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