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Article

MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.

Cell - 28 Nov 1997

Madhani H D, Styles C A, Fink G R

Abstract excerpt

Filamentous invasive growth of S. cerevisiae requires multiple elements of the mitogen-activated protein kinase (MAPK) signaling cascade that are also components of the mating pheromone response pathway. Here we show that, despite sharing several constituents, the two pathways use different MAP kinases. The Fus3 MAPK regulates mating, whereas the Kss1 MAPK regulates filamentation and invasion. Remarkably, in...

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PMID: 9393860
DOI: 10.1016/s0092-8674(00)80454-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.PMID 9393860Read ↗

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Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast.Semantic proximity Read ↗

Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.Semantic proximity Read ↗

Nuclear relocation of Kss1 contributes to the specificity of the mating response.Semantic proximity Read ↗

Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.Semantic proximity Read ↗

Phenotypic and transcriptional plasticity directed by a yeast mitogen-activated protein kinase network.Semantic proximity Read ↗

Dynamics and organization of MAP kinase signal pathways.Semantic proximity Read ↗

Mitogen-activated protein kinase (MAPK) dynamics determine cell fate in the yeast mating response.Semantic proximity Read ↗

Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.Semantic proximity Read ↗

Strains isogenic to S288C used in the yeast genome sequencing programme carry a functional KSS1 gene.Semantic proximity Read ↗

Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.Semantic proximity Read ↗

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