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Article

Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.

Cell - 29 Dec 2004

Bao Marie Z, Schwartz Monica A, Cantin Greg T, Yates John R, Madhani Hiten D

Abstract excerpt

The yeast MAPK pathways required for mating versus filamentous growth share multiple components yet specify distinct programs. The mating-specific MAPK, Fus3, prevents crosstalk between the two pathways by unknown mechanisms. Here we show that pheromone signaling induces Fus3-dependent degradation of Tec1, the transcription factor specific to the filamentation pathway. Degradation requires Fus3 kinase activity...

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Identifiers

PMID: 15620357
DOI: 10.1016/j.cell.2004.11.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.PMID 15620357Read ↗

Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast.Semantic proximity Read ↗

Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.Semantic proximity Read ↗

MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.Semantic proximity Read ↗

Phenotypic and transcriptional plasticity directed by a yeast mitogen-activated protein kinase network.Semantic proximity Read ↗

Combinatorial control required for the specificity of yeast MAPK signaling.Semantic proximity Read ↗

Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p.Semantic proximity Read ↗

The scaffold protein Ste5 directly controls a switch-like mating decision in yeast.Semantic proximity Read ↗

Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating.Semantic proximity Read ↗

Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.Semantic proximity Read ↗

Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.Semantic proximity Read ↗

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.Semantic proximity Read ↗

Nuclear relocation of Kss1 contributes to the specificity of the mating response.Semantic proximity Read ↗

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