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Article

Genetic causes of resistance to vitamin K antagonists in Polish patients: a novel p.Ile123Met mutation in VKORC1 gene.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jul 2018

Wzorek Joanna, Wypasek Ewa, Awsiuk Magdalena, Potaczek Daniel P, Undas Anetta

Abstract excerpt

: Mutations in the genes encoding vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) largely contribute to the inter-individual variations in vitamin K antagonists (VKAs) dose requirements. Up to 50% of the dosage variability can be explained by genetic polymorphisms in these genes. We sought to identify the mutations responsible for VKA resistance in a series of Polish...

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Identifiers

PMID: 29794812
DOI: 10.1097/MBC.0000000000000737

Genes

VKORC1

Variants

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