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Article

Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease.

World journal of gastroenterology - 28 Jul 2008

Rigoli Luciana, Romano Claudio, Caruso Rosario Alberto, Lo Presti Maria A, Di Bella Chiara, Procopio Vincenzo, Lo Giudice Giuseppina, Amorini Maria, Costantino Giuseppe, Sergi Maria D, Cuppari Caterina, Calabro Giovanna Elisa, Gallizzi Romina, Salpietro Carmelo Damiano, Fries Walter

Abstract excerpt

AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of...

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Identifiers

PMID: 18680223
DOI: 10.3748/wjg.14.4454
PMCID: PMC2731270

Genes

NOD2
TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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