Article
The cyclic GMP-dependent protein kinase II gene associates with gout disease: identified by genome-wide analysis and case-control study.
Annals of the rheumatic diseases - 1 Jul 2009
Chang S-J, Tsai M-H, Ko Y-C, Tsai P-C, Chen C-J, Lai H-M
Abstract excerpt
OBJECTIVE: To identify the position of a gout susceptibility gene. METHODS: A genome-wide scan was performed using 382 random polymorphic microsatellite markers spread across 22 autosomes in a Taiwanese family with gout to screen for the gout susceptibility genetic marker. Its association with gout by 33 single nucleotide polymorphisms (SNP) in 148 matched case-control subjects was confirmed. The family with gout...
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