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Article

Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene.

Toxicology and applied pharmacology - 15 Jul 2008

Erichsen Thomas J, Ehmer Ursula, Kalthoff Sandra, Lankisch Tim O, Müller Tordis M, Munzel Peter A, Manns Michael P, Strassburg Christian P

Abstract excerpt

UDP glucuronosyltransferases (UGTs) play an important role for drug detoxification and toxicity. UGT function is genetically modulated by single nucleotide polymorphisms (SNPs) which lead to the expression of functionally altered protein, or altered expression levels. UGT1A4 activity includes anticonvulsants, antidepressants and environmental mutagens. In this study the induction of the human UGT1A4 gene and a...

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Identifiers

PMID: 18433817
DOI: 10.1016/j.taap.2008.02.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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