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Article

Library Construction for Mutation Identification by Whole-Genome Sequencing.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Smith Harold E

Abstract excerpt

Next-generation sequencing provides a rapid and powerful method for mutation identification. Herein is described a workflow for sample preparation to allow the simultaneous mapping and identification of candidate mutations by whole-genome sequencing in Caenorhabditis elegans. The protocol is designed for small numbers of worms to accommodate classes of mutations, such as lethal and sterile alleles, that are...

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Identifiers

PMID: 26423963
DOI: 10.1007/978-1-4939-2842-2_1
PMCID: PMC6294290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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