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Article

Potassium channel KCNH2 K897T polymorphism and cardiac repolarization during exercise test: The Finnish Cardiovascular Study.

Scandinavian journal of clinical and laboratory investigation - 1 Jan 2008

Koskela J, Laiho J, KäHönen M, Rontu R, Lehtinen R, Viik J, Niemi M, Niemelä K, Kööbi T, Turjanmaa V, Pörsti I, Lehtimäki T, Nieminen T

Abstract excerpt

OBJECTIVE: Cardiac repolarization is regulated, in part, by the KCNH2 gene, which encodes a rapidly activating component of the delayed rectifier potassium channel. The gene expresses a functional single nucleotide polymorphism, K897T, which changes the biophysical properties of the channel. The objective of this study was to evaluate whether this polymorphism influences two indices of repolarization--the QT...

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Identifiers

PMID: 17852802
DOI: 10.1080/00365510701496488

Genes

KCNH2

Variants

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Potassium channel KCNH2 K897T polymorphism and cardiac repolarization during exercise test: The Finnish Cardiovascular Study.PMID 17852802Read ↗

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