Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast.

doi:10.1016/0092-8674(90)90075-p

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Article

Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast.

Cell - 15 Jun 1990

Sandgren E P, Luetteke N C, Palmiter R D, Brinster R L, Lee D C

Abstract excerpt

Metallothionein-directed expression of TGF alpha in transgenic mice induced a spectrum of changes in the growth and differentiation of certain adult tissues. First, TGF alpha promoted a uniform epithelial hyperplasia of several organs without otherwise causing major alterations in tissue architec...

Topics

Animals
Animals, Newborn
DNA
Epithelium
Female
Growth Hormone
Hyperplasia
Mammary Neoplasms, Experimental
Metallothionein
Metaplasia
Mice
Mice, Transgenic
Organ Size
Pancreas
Phenotype
RNA
Recombinant Fusion Proteins
Sulfates

Source

Open in PubMed

Identifiers

PMID: 1693546
DOI: 10.1016/0092-8674(90)90075-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1693546-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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