Article
Tra2beta as a novel mediator of vascular smooth muscle diversification.
Circulation research - 29 Aug 2008
Shukla Supriya, Fisher Steven A
Abstract excerpt
Transformer splicing regulatory proteins determine the sexually dimorphic traits of Drosophila. The role of the vertebrate homologs of Tra-2 in phenotypic specification is undefined. We are using the alternative splicing of the MYPT1 E23 exon as a model for the study of smooth muscle diversification into fast and slow contractile phenotypes. Tra2beta mRNA and protein is expressed at up to 10-fold higher levels in...
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