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Article

Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle.

Nature communications - 3 Jun 2020

Chestnut Brendan, Casie Chetty Satish, Koenig Andrew L, Sumanas Saulius

Abstract excerpt

Cell fate decisions involved in vascular and hematopoietic embryonic development are still poorly understood. An ETS transcription factor Etv2 functions as an evolutionarily conserved master regulator of vasculogenesis. Here we report a single-cell transcriptomic analysis of hematovascular development in wild-type and etv2 mutant zebrafish embryos. Distinct transcriptional signatures of different types of...

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Identifiers

PMID: 32493965
DOI: 10.1038/s41467-020-16515-y
PMCID: PMC7271194

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