Article

Coupled beta and high-frequency oscillations emerge from synchronized bursting in a minimal model of the parkinsonian subthalamic nucleus

2026-04-01

Abstract excerpt

Local field potentials recorded from the subthalamic nucleus (STN) in Parkinson’s disease (PD) exhibit a distinctive multiscale spectral signature: exaggerated beta-band oscillations (13-30 Hz) coupled to high-frequency oscillations (HFOs, 200-400 Hz), with HFO amplitude being phase-locked to the beta cycle. This phase-amplitude coupling (PAC) has been identified as a promising biomarker of the parkinsonian state,...

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Literature Corpus work: 644945c9-e8ab-5c98-9bfc-c878eb2018b4
DOI: 10.64898/2026.03.30.715339

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