Article
Adaptive mutations in the signal peptide of the type 1 fimbrial adhesin of uropathogenic Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2008
Ronald Leah S, Yakovenko Olga, Yazvenko Nina, Chattopadhyay Sujay, Aprikian Pavel, Thomas Wendy E, Sokurenko Evgeni V
Abstract excerpt
Signal peptides (SPs) are critical for protein transport across cellular membranes, have a highly conserved structure, and are cleaved from the mature protein upon translocation. Here, we report that naturally occurring mutations in the SP of the adhesive, tip-associated subunit of type 1 fimbriae (FimH) are positively selected in uropathogenic Escherichia coli. On the one hand, these mutations have a detrimental...
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