Article
Redox signaling regulates transcriptional activity of the Ca2+-dependent repressor DREAM.
Antioxidants & redox signaling - 1 Apr 2011
Rivas Marcos, Aurrekoetxea Koldo, Mellström Britt, Naranjo José R
Abstract excerpt
DREAM/KChIP3 (Downstream Regulatory Element Antagonist Modulator) is a multifunctional Ca(2+)-binding protein that acts in the nucleus as a Ca(2+)-dependent transcriptional repressor. Binding to DNA and repressor activity of DREAM is regulated by Ca(2+), specific post-translational modifications as well as by protein-protein interactions with several nucleoproteins. Here, using the yeast two-hybrid assay, we...
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