Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ca(2+)-dependent prodynorphin transcriptional derepression in neuroblastoma cells is exerted through DREAM protein activity in a kinase-independent manner.

Molecular and cellular neurosciences - 1 Feb 2003

Campos David, Jiménez-Díaz Lydia, Carrión Angel M

Abstract excerpt

Prodynorphin transcription has been postulated as an important molecular mechanism involved in adaptation/repair processes. Expression of prodynorphin is modulated according to the levels of the second messengers cAMP and Ca(2+). In the neuroblastoma cell lines, the increase of prodynorphin mRNA levels is coupled to an elevation of intracellular cAMP levels. Promoter analyses have revealed that the DRE site, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caffeine
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System

Share to Colforsin

Share to Cyclic AMP-Dependent Protein Kinases

Share to Enkephalins

Share to Genes, Regulator

Share to Neuroblastoma

Source

Identifiers

PMID: 12676525
DOI: 10.1016/s1044-7431(03)00040-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ca(2+)-dependent prodynorphin transcriptional derepression in neuroblastoma cells is exerted through DREAM protein activity in a kinase-independent manner.PMID 12676525Read ↗

DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.Semantic proximity Read ↗

Protein Kinase A-Dependent Derepression of the Human Prodynorphin Gene via Differential Binding to an Intragenic Silencer ElementSemantic proximity Read ↗

Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling.Semantic proximity Read ↗

Redox signaling regulates transcriptional activity of the Ca2+-dependent repressor DREAM.Semantic proximity Read ↗

The DREAM-DRE interaction: key nucleotides and dominant negative mutants.Semantic proximity Read ↗

Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.Semantic proximity Read ↗

A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription.Semantic proximity Read ↗

A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiationSemantic proximity Read ↗

Pituitary adenylyl cyclase-activating polypeptide receptor re-sensitization induces plastic changes in the dopaminergic phenotype in the mature avian retina.Semantic proximity Read ↗

Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression.Semantic proximity Read ↗

Expression of the neurotrophin receptor trkB is regulated by the cAMP/CREB pathway in neuronsSemantic proximity Read ↗

Prolyl Endopeptidase Is Involved in Cellular Signalling in Human Neuroblastoma SH-SY5Y CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.