Article
Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2A/B56α.
BioMed research international - 1 Jan 2019
Tang Yan, Yang JungWoo, Zheng Wang, Tang Jingfeng, Chen Xing-Zhen, Yang Jianzheng, Wang Zuocheng
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is associated with a number of cellular defects such as hyperproliferation, apoptosis, and dedifferentiation. Mutations in polycystin-1 (PC1) account for ∼85% of ADPKD. Here, we showed that wild-type (WT) or mutant PC1 composed of the last five transmembrane (TM) domains and the C-terminus (termed PC1-5TMC) inhibits cell proliferation and protein translation,...
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