Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover.

Cellular signalling - 1 Nov 2008

Densham Ruth M, Todd Daniel E, Balmanno Kathy, Cook Simon J

Abstract excerpt

The conditional kinase DeltaMEKK3:ER allows activation of JNK, p38 and ERK1/2 without overt cellular stress or damage and has proved useful in understanding how these pathways regulate apoptosis and cell cycle progression. We have previously shown that activation of DeltaMEKK3:ER causes a sustained G(1) cell cycle arrest which requires p21(CIP1), with ERK1/2 and p38 cooperating to promote p21(CIP1) expression. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to G1 Phase
Share to Glycogen Synthase Kinase 3
Share to Glycogen Synthase Kinase 3 beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to p38 Mitogen-Activated Protein Kinases

Share to Phosphothreonine

Share to raf Kinases

Source

Identifiers

PMID: 18664382
DOI: 10.1016/j.cellsig.2008.07.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover.PMID 18664382Read ↗

Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis.Semantic proximity Read ↗

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.Semantic proximity Read ↗

Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.Semantic proximity Read ↗

BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.Semantic proximity Read ↗

Cdk2 and Cdk4 cooperatively control the expression of Cdc2.Semantic proximity Read ↗

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.Semantic proximity Read ↗

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.Semantic proximity Read ↗

HBx protein modulates PI3K/Akt pathway to overcome genotoxic stress-induced destabilization of cyclin D1 and arrest of cell cycle.Semantic proximity Read ↗

Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1.Semantic proximity Read ↗

Cdk1 coordinates cell-surface growth with the cell cycle.Semantic proximity Read ↗

Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.Semantic proximity Read ↗

Pachytene exit controlled by reversal of Mek1-dependent phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.