Article
Correlation between the secondary structure of pre-mRNA introns and the efficiency of splicing in Saccharomyces cerevisiae.
BMC genomics - 29 Jul 2008
Rogic Sanja, Montpetit Ben, Hoos Holger H, Mackworth Alan K, Ouellette Bf Francis, Hieter Philip
Abstract excerpt
BACKGROUND: Secondary structure interactions within introns have been shown to be essential for efficient splicing of several yeast genes. The nature of these base-pairing interactions and their effect on splicing efficiency were most extensively studied in ribosomal protein gene RPS17B (previously known as RP51B). It was determined that complementary pairing between two sequence segments located downstream of...
Topics
- Algorithms
- Base Pairing
- Computational Biology
- Genes, Fungal
- Genome, Fungal
- Introns
- Mutation
- Nucleic Acid Conformation
- RNA Precursors
- RNA Splicing
- RNA, Fungal
- RNA, Messenger
- Ribosomal Proteins
- Saccharomyces cerevisiae