Article
The effects of structure on pre-mRNA processing and stability.
Methods (San Diego, Calif.) - 1 Aug 2017
Soemedi Rachel, Cygan Kamil J, Rhine Christy L, Glidden David T, Taggart Allison J, Lin Chien-Ling, Fredericks Alger M, Fairbrother William G
Abstract excerpt
Pre-mRNA molecules can form a variety of structures, and both secondary and tertiary structures have important effects on processing, function and stability of these molecules. The prediction of RNA secondary structure is a challenging problem and various algorithms that use minimum free energy, maximum expected accuracy and comparative evolutionary based methods have been developed to predict secondary...
Topics
- Animals
- Exons
- G-Quadruplexes
- Humans
- Immunity, Innate
- Introns
- Mutation
- RNA Folding
- RNA Precursors
- RNA Splicing
- RNA, Double-Stranded
- Zebrafish