Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Oct 2008

Wiegand Irith, Marr Alexandra K, Breidenstein Elena B M, Schurek Kristen N, Taylor Patrick, Hancock Robert E W

Abstract excerpt

Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ciprofloxacin
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to DNA Transposable Elements

Share to Drug Resistance, Multiple, Bacterial

Share to Genomic Library

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 18663021
DOI: 10.1128/AAC.00233-08
PMCID: PMC2565895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa.PMID 18663021Read ↗

Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM).Semantic proximity Read ↗

Identification of Pseudomonas aeruginosa genes associated with antibiotic susceptibility.Semantic proximity Read ↗

The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants.Semantic proximity Read ↗

The role of mutators in the emergence of antibiotic-resistant bacteria.Semantic proximity Read ↗

Bacterial hypermutation in cystic fibrosis, not only for antibiotic resistance.Semantic proximity Read ↗

A novel papillation assay for the identification of genes affecting mutation rate in Pseudomonas putida and other pseudomonads.Semantic proximity Read ↗

Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.Semantic proximity Read ↗

Molecular basis of the phenotypic variants arising from a Pseudoalteromonas lipolytica mutator.Semantic proximity Read ↗

Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach.Semantic proximity Read ↗

The role of the Pseudomonas aeruginosa hypermutator phenotype on the shift from acute to chronic virulence during respiratory infection.Semantic proximity Read ↗

Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility.Semantic proximity Read ↗

Screening of the PA14NR Transposon Mutant Library Identifies Genes Involved in Resistance to Bacteriophage Infection in Pseudomomas aeruginosa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.