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Article

Molecular basis of the phenotypic variants arising from a Pseudoalteromonas lipolytica mutator.

Microbial genomics - 1 Oct 2023

Zeng Zhenshun, Gu Jiayu, Lin Shituan, Li Qian, Wang Weiquan, Guo Yuexue

Abstract excerpt

Bacterial deficiencies in the DNA repair system can produce mutator strains that promote adaptive microevolution. However, the role of mutator strains in marine Pseudoalteromonas, capable of generating various gain-of-function genetic variants within biofilms, remains largely unknown. In this study, inactivation of mutS in Pseudoalteromonas lipolytica conferred an approximately 100-fold increased resistance to...

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PMID: 37850970
DOI: 10.1099/mgen.0.001118
PMCID: PMC10634453

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