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Article

Relative strength of 5' splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA.

BMB reports - 1 Mar 2021

Choi Namjeong, Liu Yongchao, Oh Jagyeong, Ha Jiyeon, Ghigna Claudia, Zheng Xuexiu, Shen Haihong

Abstract excerpt

Bcl-x, a member of the Bcl-2 family, plays a key role in apoptosis. Alternative splicing of Bcl-x pre-mRNA through alternative 5' splice-site selection produces an anti-apoptotic mRNA isoform that includes exon 2b and a pro-apoptotic Bcl-x mRNA isoform that excludes exon 2b. Here we used Bcl-x minigene and identified SRSF2 and SRSF6 as two regulatory factors of 5' splice-site selection of Bcl-x pre-mRNA. We...

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PMID: 33050987
PMCID: PMC8016662

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