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Article

Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.

Cell reports - 13 Apr 2021

Daniels Noah J, Hershberger Courtney E, Gu Xiaorong, Schueger Caroline, DiPasquale William M, Brick Jonathan, Saunthararajah Yogen, Maciejewski Jaroslaw P, Padgett Richard A

Abstract excerpt

Vertebrates have evolved three paralogs, termed LUC7L, LUC7L2, and LUC7L3, of the essential yeast U1 small nuclear RNA (snRNA)-associated splicing factor Luc7p. We investigated the mechanistic and regulatory functions of these putative splicing factors, of which one (LUC7L2) is mutated or deleted in myeloid neoplasms. Protein interaction data show that all three proteins bind similar core but distinct regulatory...

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Identifiers

PMID: 33852859
DOI: 10.1016/j.celrep.2021.108989
PMCID: PMC8078730

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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