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Article

The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

8 Jan 2019

Abstract excerpt

Cancer sequencing studies have implicated regulators of pre-mRNA splicing as important disease determinants in acute myeloid leukemia (AML), but the underlying mechanisms have remained elusive. We hypothesized that "non-mutated" splicing regulators may also play a role in AML biology and therefore conducted an in vivo shRNA screen in a mouse model of CEBPA mutant AML. This has led to the identification of the...

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PMID: 30635567
DOI: 10.1038/s41467-018-08076-y

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