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Article

Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library

6 Oct 2017

Abstract excerpt

phase arrest and represses cell proliferation. We further report that the carboxyl terminus of XBP1-u, which differs from that of its spliced form (XBP1-s) due to a codon shift, binds and stabilizes mouse double minute homolog 2 (MDM2) protein, a negative regulator of p53, by inhibiting its self-ubiquitination. Concomitantly, XBP-u overexpression enhances tumorigenesis by positively regulating MDM2. Together, our...

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PMID: 29057323
DOI: 10.1126/sciadv.1701383

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