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Article

Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein.

Nucleic acids research - 1 Mar 2008

Sakakibara Nozomi, Kasiviswanathan Rajesh, Melamud Eugene, Han Mimi, Schwarz Frederick P, Kelman Zvi

Abstract excerpt

Minichromosome maintenance (MCM) helicases are the presumptive replicative helicases, thought to separate the two strands of chromosomal DNA during replication. In archaea, the catalytic activity resides within the C-terminal region of the MCM protein. In Methanothermobacter thermautotrophicus the N-terminal portion of the protein was shown to be involved in protein multimerization and binding to single and...

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Identifiers

PMID: 18184696
DOI: 10.1093/nar/gkm1160
PMCID: PMC2275104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein.PMID 18184696Read ↗

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