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Article

Double hexamer disruption and biochemical activities of Methanobacterium thermoautotrophicum MCM.

The Journal of biological chemistry - 23 Dec 2005

Fletcher Ryan J, Shen Jingping, Gómez-Llorente Yacob, Martín Carmen San, Carazo José M, Chen Xiaojiang S

Abstract excerpt

Methanobacterium thermoautotrophicum MCM (mtMCM) is a helicase required for DNA replication. Previous electron microscopy studies have shown mtMCM in several oligomeric forms. However, biochemical studies suggest that mtMCM is a dodecamer, likely a double hexamer (dHex). The crystal structure of the N-terminal fragment of mtMCM reveals a stable dHex architecture. To further confirm that the dHex is not an...

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PMID: 16221679
DOI: 10.1074/jbc.M509773200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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