Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors.

Cancer research - 15 Jun 2013

Simon Susanne, Grabellus Florian, Ferrera Loretta, Galietta Luis, Schwindenhammer Benjamin, Mühlenberg Thomas, Taeger Georg, Eilers Grant, Treckmann Juergen, Breitenbuecher Frank, Schuler Martin, Taguchi Takahiro, Fletcher Jonathan A, Bauer Sebastian

Abstract excerpt

Gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT or platelet-derived growth factor receptor α(PDGFRA), which can be therapeutically targeted by tyrosine kinase inhibitors (TKI) such as imatinib. Despite long-lasting responses, most patients eventually progress after TKI therapy. The calcium-dependent chloride channel DOG1 (ANO1/TMEM16A), which is strongly and specifically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Chloride Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Stromal Tumors

Share to Imatinib Mesylate

Share to Piperazines

Share to Proto-Oncogene Proteins c-kit

Share to Pyrimidines

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 23576565
DOI: 10.1158/0008-5472.CAN-12-3839
PMCID: PMC3694361

Genes

KIT
IGFBP5
ANO1
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors.PMID 23576565Read ↗

Mapping of DOG1 expression in colorectal carcinomas.Semantic proximity Read ↗

The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status.Semantic proximity Read ↗

Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors.Semantic proximity Read ↗

A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors.Semantic proximity Read ↗

Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations.Semantic proximity Read ↗

DOG1 overexpression is associated with mismatch repair deficiency and BRAF mutations but unrelated to cancer progression in colorectal cancer.Semantic proximity Read ↗

What is New in Gastrointestinal Stromal Tumor?Semantic proximity Read ↗

ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.Semantic proximity Read ↗

DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors.Semantic proximity Read ↗

KITlow Cells Mediate Imatinib Resistance in Gastrointestinal Stromal TumorSemantic proximity Read ↗

Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors.Semantic proximity Read ↗

MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.