Article
A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors.
The American journal of surgical pathology - 1 Feb 2008
Espinosa Inigo, Lee Cheng-Han, Kim Mi Kyung, Rouse Bich-Tien, Subramanian Subbaya, Montgomery Kelli, Varma Sushama, Corless Christopher L, Heinrich Michael C, Smith Kevin S, Wang Zhong, Rubin Brian, Nielsen Torsten O, Seitz Robert S, Ross Douglas T, West Robert B, Cleary Michael L, van de Rijn Matt
Abstract excerpt
Gastrointestinal stromal tumors (GIST) occur primarily in the wall of the intestine and are characterized by activating mutations in the receptor tyrosine kinases genes KIT or PDGFRA. The diagnosis of GIST relies heavily on the demonstration of KIT/CD117 protein expression by immunohistochemistry. However, KIT expression is absent in approximately 4% to 15% of GIST and this can complicate the diagnosis of GIST in...
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