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Article

Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11.

BMC cancer - 15 Oct 2010

Gregory-Bryson Emmalena, Bartlett Elizabeth, Kiupel Matti, Hayes Schantel, Yuzbasiyan-Gurkan Vilma

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors. This study evaluated the role of c-KIT in canine GISTs; specifically, we investigated activating mutations in exons 8, 9, 11, 13, and 17 of c-KIT and exons 12, 14, and 18 of platelet-derived growth factor receptor, alpha...

Topics

Animals
Base Sequence
DNA Mutational Analysis
Disease Models, Animal
Dogs
Exons
Female
Gastrointestinal Stromal Tumors
Humans
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Proto-Oncogene Proteins c-kit

Receptor, Platelet-Derived Growth Factor alpha

Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20950418
DOI: 10.1186/1471-2407-10-559
PMCID: PMC2970610

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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