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Article

A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.

PloS one - 23 Jul 2008

Martinez Gilbert Q, Maduke Merritt

Abstract excerpt

BACKGROUND: ClC-Kb and ClC-Ka are homologous chloride channels that facilitate chloride homeostasis in the kidney and inner ear. Disruption of ClC-Kb leads to Bartter's Syndrome, a kidney disease. A point mutation in ClC-Kb, R538P, linked to Bartter's Syndrome and located in the C-terminal cytoplasmic domain was hypothesized to alter electrophysiological properties due to its proximity to an important...

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Identifiers

PMID: 18648499
DOI: 10.1371/journal.pone.0002746
PMCID: PMC2447174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.PMID 18648499Read ↗

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