Article
D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2008
Vlach Jirí, Lipov Jan, Rumlová Michaela, Veverka Václav, Lang Jan, Srb Pavel, Knejzlík Zdenek, Pichová Iva, Hunter Eric, Hrabal Richard, Ruml Tomás
Abstract excerpt
Despite extensive data demonstrating that immature retroviral particle assembly can take place either at the plasma membrane or at a distinct location within the cytoplasm, targeting of viral precursor proteins to either assembly site still remains poorly understood. Biochemical data presented here suggest that Tctex-1, a light chain of the molecular motor dynein, is involved in the intracellular targeting of...
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