Article
Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin.
Traffic (Copenhagen, Denmark) - 1 Nov 2006
Yeh Ting-Yu, Peretti Diego, Chuang Jen-Zen, Rodriguez-Boulan Enrique, Sung Ching-Hwa
Abstract excerpt
Post-Golgi to apical surface delivery in polarized epithelial cells requires the cytoplasmic dynein motor complex. However, the nature of dynein-cargo interactions and their underlying regulation are largely unknown. Previous studies have shown that the apical surface targeting of rhodopsin requires the dynein light chain, Tctex-1, which binds directly to both dynein intermediate chain (IC) and rhodopsin. In this...
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