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Exploitation of Microtubule Cytoskeleton and Dynein during Parvoviral Traffic toward the Nucleus

11 Sept 2003

Abstract excerpt

Canine parvovirus (CPV), a model virus for the study of parvoviral entry, enters host cells by receptor-mediated endocytosis, escapes from endosomal vesicles to the cytosol, and then replicates in the nucleus. We examined the role of the microtubule (MT)-mediated cytoplasmic trafficking of viral particles toward the nucleus. Immunofluorescence and immunoelectron microscopy showed that capsids were transported...

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PMID: 12970411
DOI: 10.1128/jvi.77.19.10270-10279.2003

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