Article
Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging.
Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006
Wiktor-Brown Dominika M, Hendricks Carrie A, Olipitz Werner, Engelward Bevin P
Abstract excerpt
Mitotic homologous recombination (HR) is critical for the repair of double-strand breaks, and conditions that stimulate HR are associated with an increased risk of deleterious sequence rearrangements that can promote cancer. Because of the difficulty of assessing HR in mammals, little is known about HR activity in mammalian tissues or about the effects of cancer risk factors on HR in vivo. To study HR in vivo, we...
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