Article
Controlling the selectivity and stability of proteins by new strategies in directed evolution: the case of organocatalytic enzymes.
Ernst Schering Foundation symposium proceedings - 1 Jan 2007
Reetz M T
Abstract excerpt
The directed evolution of functional enzymes as catalysts in organic reactions has emerged as a powerful method of protein engineering. This includes the directed evolution of enantioselective enzymes as pioneered by the author. In recent years the challenges in this new area of asymmetric catalysis has shifted to solving the problem of probing protein sequence space more efficiently than before. Iterative...
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