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Watching the Watcher: Regulation of p53 by Mitochondria

26 Feb 2009

Abstract excerpt

p53 has been referred to as the 'guardian of the genome' because of its role in protecting the cell from DNA damage. p53 performs its duties by regulating cell-cycle progression and DNA repair and, in cases of irreparable DNA damage, by executing programmed cell death. Mitochondria are an important target of transcription-dependent and -independent actions of p53 to carry out the apoptotic function. However,...

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PMID: 19243304
DOI: 10.2217/14796694.5.1.117

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