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Article

MOMP, cell suicide as a BCL-2 family business

20 Oct 2017

Abstract excerpt

Apoptosis shapes development and differentiation, has a key role in tissue homeostasis, and is deregulated in cancer. In most cases, successful apoptosis is triggered by mitochondrial outer membrane permeabilization (MOMP), which defines the mitochondrial or intrinsic pathway and ultimately leads to caspase activation and protein substrate cleavage. The mitochondrial apoptotic pathway centered on MOMP is...

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Identifiers

PMID: 29053143
DOI: 10.1038/cdd.2017.179

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